中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (29): 5379-5383.doi: 10.3969/j.issn. 2095-4344.2012.29. 013

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

异种松质骨修复兔桡骨节段性骨缺损

魏冀荣1，章 莹2，林永亮3   

  1. 1南方医科大学研究生院，广东省广州市 510515；
    2解放军广州军区广州总医院骨科医院创伤骨科，广东省广州市 510010；
    3广东冠昊生物科技有限公司研发部，广东省广州市 510663
  • 收稿日期:2012-03-22 修回日期:2012-03-22 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 章莹，博士，硕士生导师，主任医师，解放军广州军区广州总医院骨科医院创伤骨科，广东省广州市 510010
  • 作者简介:魏冀荣★，男，1985年生，山西省太原市人，汉族，2012年南方医科大学毕业，硕士，医师，主要从事骨缺损修复方面研究。 fimmutrumpet@ qq.com

Xenogeneic cancellous bone for repairing segmental bone defects in rabbit radius

Wei Ji-rong1, Zhang Ying2, Lin Yong-liang3   

  1. 1School of Graduated Student, Southern Medical University, Guangzhou 510515, Guangdong Province, China;
    2Department of Traumatic Orthopedics, General Hospital of Guangzhou Military Command of Chinese PLA, Guangzhou 510510, Guangdong Province, China;
    3Department of Research and Development, Guangdong Guanhao Biological Technology Company, Guangzhou 510663, Guangdong Province, China
  • Received:2012-03-22 Revised:2012-03-22 Online:2012-07-15 Published:2012-07-15
  • Contact: Zhang Ying, Doctor, Master’s supervisor, Chief physician, Department of Traumatic Orthopedics General Hospital of Guangzhou Military Command of Chinese PLA, Guangzhou 510510, Guangdong Province, China
  • About author:Wei Ji-rong★, Master, Physician, School of Graduated Student, Southern Medical University, Guangzhou 510515, Guangdong Province, China fimmutrumpet@ qq.com

PDF

366

被引次数

5

摘要：

背景：异种松质骨具有天然多孔结构，有利于新骨长入，经处理可完全消除抗原性，不引起免疫排斥反应，具有良好的骨传导性能。
目的：评价异种骨修复兔桡骨节段性骨缺损的效果。
方法：将36只新西兰白兔随机均分3组，制作单侧15 mm桡骨节段性骨缺损模型，实验组植入生物型异种骨，对照组植入深冻兔异体骨，空白组未植骨。术后4，8，12周进行一般情况、大体解剖、X射线及组织学观察。
结果与结论：术后4，8，12周实验组与对照组骨缺损逐步修复，空白组骨缺损未修复，实验组与对照组影像学和组织学评分均高于空白组(P < 0.05)，实验组与对照组影像学和组织学评分差异无显著性意义。表明生物型异种骨可较好修复骨缺损，修复效果与异体骨相当。

关键词: 异种骨, 异体骨, 骨缺损, 再血管化, 骨愈合, 兔, 生物材料

Abstract:

BACKGROUND: Xenogeneic cancellous bone has a natural porous structure that facilitates the ingrowth of new bone. Besides, its antigenicity can be eliminated completely after treatment and cannot induce immune rejection. Moreover, it has good bone conduction.
OBJECTIVE: To evaluate the effect of xenogeneic bone on the repair of segmental bone defects in rabbit radius.
METHODS: Totally 36 rabbits (4-6 months old, 2.5-3.5 kg, no gender limitations) were randomly divided into three groups: experimental group, control group and blank group. A rabbit model of 15 mm-long segmental bone defects in the radius was established. Rabbits in the experimental group were implanted with biological xenogeneic bone, and those in the control group were implanted with deep frozen allogenic bone, while the blank group had no treatment. At weeks 4, 8 and 12 after operation, rabbits in the three groups were observed by general observation, anatomy observation, X-ray examination and histological examination.
RESULTS AND CONCLUSION: At weeks 4, 8 and 12 after operation, bone defects in the experimental and control groups were repaired gradually, but no repair was found in the blank group. The radiographic and histological scores were both higher in the experimental and control groups than the blank group (P < 0.05). The radiographic and histological scores between the experimental and control groups had no significant difference. These results suggest that biological xenogeneic bone is good to repair bone defects; in addition, the repair effect of biological xenogeneic bone is the same as that of xenogeneic bone.

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